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ExpressMAX™ Expression-ready Human GPCR ORF Clones
5-hydroxytryptamine (Serotonin) Receptor 1D
ExpressMAX™ Expression-ready Human GPCR ORF Clones
Product Overview:
GPCR for serotonin, found in nociceptors throughout the body. The anti-migraine action of “triptan” Drugs involves the activation of serotonin subtype 1D (HT1D) Receptors expressed on “pain-responsive” trigeminal primary afferents. HT1D Receptors are present in a similar subpopulation of trigeminal and dorsal root ganglia neurons and in the central terminals of primary afferents.
Advantages & Features
- Native structure.
- Wide range: A large collection of ExpressMAX™ GPCR ORF Clones availables.
- Highest levels of GPCR expression: on surface cell lines, > 50% of TAG detection by cytometry.
- Wide spectrum: of strong constitutive promoters.
- Complete solution: it contains all necessary elements for maximum receptor expression.
- Ready-to-use solution: avoids cloning steps, DNA ready to transfect.
- Easy protocol and detection: the whole procedure is simple, with minimal handling.
- Neomycin resistance.
- Ampicillin bacterial selection.
Specifications
- Plasmid size: 7129 pb
- Promoter: PEF1α
- ORF Sequence (GenBank based): NM_012852
- Protein Sequence (SwissProt): P28565
- Bacterial Selection Antibiotics: Ampicillin
- Mammalian Selection Antibiotic: Neomycin
- Alternative names: 5HT1D